{"id":1376,"date":"2022-06-15T00:00:00","date_gmt":"2022-06-14T22:00:00","guid":{"rendered":"https:\/\/preprod.retinegallien.com\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/"},"modified":"2022-06-15T00:00:00","modified_gmt":"2022-06-14T22:00:00","slug":"disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review","status":"publish","type":"publication","link":"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/","title":{"rendered":"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review"},"content":{"rendered":"<p><strong>Revista Brasileira de Oftalmologia&nbsp;81(10)&nbsp;April 2022<\/strong><\/p>\n<p>Andreas Di-Luciano1 , Wai-Ching Lam2 , <strong>Laurent Velasque3<\/strong> , Eduardo Kenstelman4 ,Rodrigo M. Torres5 , Rosa Alvarado-Villacorta6 , Manish Nagpal71 Flying Eye Hospital, Orbis International, New York, United States.2 Deparment of Ophthalmology LKS Faculty of Medicine University Hong Kong, Hong Kong3<strong> Centre Retine Gallien Bordeaux, <\/strong>France4 HOlhos S\u00e3o Gon\u00e7alo, Rio de Janeiro, Brazil5 ROMAT Creator center, Colonia Avellaneda, Entre R\u00edos, Argentina.6 Research Unit, Clinica Vista, Lima, Peru7 Retina foundation, Gujarat, India<br \/>\n<em>(<\/em><br \/>\n&nbsp;<br \/><\/br \/>ABSTRACT The objective of this article was to review the disorganization of inner retinal layers as a biomarker in diabetic macular edema. A systematic search was conducted in PubMed\u00ae\/MEDLINE\u00ae, Cochrane and Embase until August 2021. The keywords used were: \u201cdisorganization of inner retinal layers (DRIL)\u201d, \u201cdiabetic macular edema (DME)\u201d and \u201cbiomarkers\u201d. No restrictions were imposed on the types of study to be included. The studies selected for eligibility were those that included the diagnosis of diabetic macular edema (center involved, resolved), that were well documented with spectral domain optical coherence tomography, that included disorganization of inner retinal layers as one of the reported alterations, with a follow-up of at least 3 months, and those in which the best corrected visual acuity was evaluated pre and post. There were no limitations regarding the type of treatment established. References of identified studies were searched for additional relevant articles. Articles not published in peer review journals were excluded. All studies were evaluated by two investigators independently. When one of them was in doubt, it was assessed by a third evaluator. A total of seven studies were included. Four were retrospective, longitudinal cohort study and three cross-sectional observational. Regarding the population studied, 61.5% were men and 38.4% were women, most of them had diabetes mellitus type 2 (85.8%). Regarding the stage of diabetes, the percentage of patients with mild nonproliferative diabetic retinopathy was 28.2%, with moderate nonproliferative diabetic retinopathy was 28.5%, with severe nonproliferative diabetic retinopathy was 15.9% and with nonproliferative diabetic retinopathy was 27.4%. In 100% of the studies, the diagnosis of diabetic macular edema in the center involved was included by spectral domain optical coherence tomography (Heidelberg). In all the studies, the presence of disorganization of inner retinal layers was recorded and its association with best corrected visual acuity was evaluated. The measurement was carried out using the LogMAR scale. In all the studies, the presence or absence of disorganization of inner retinal layers was associated with the best corrected worse\/better final visual acuity using p<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"class_list":["post-1376","publication","type-publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Disorganization of the inner retinal layers in diabeticmacular edema: systematic review - R\u00e9tine Gallien<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review - R\u00e9tine Gallien\" \/>\n<meta property=\"og:description\" content=\"Revista Brasileira de Oftalmologia&nbsp;81(10)&nbsp;April 2022 Andreas Di-Luciano1 , Wai-Ching Lam2 , Laurent Velasque3 , Eduardo Kenstelman4 ,Rodrigo M. Torres5 , Rosa Alvarado-Villacorta6 , Manish Nagpal71 Flying Eye Hospital, Orbis International, New York, United States.2 Deparment of Ophthalmology LKS Faculty of Medicine University Hong Kong, Hong Kong3 Centre Retine Gallien Bordeaux, France4 HOlhos S\u00e3o Gon\u00e7alo, Rio [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/\" \/>\n<meta property=\"og:site_name\" content=\"R\u00e9tine Gallien\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/en\\\/publication\\\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\\\/\",\"url\":\"https:\\\/\\\/www.retinegallien.com\\\/en\\\/publication\\\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\\\/\",\"name\":\"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review - R\u00e9tine Gallien\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/#website\"},\"datePublished\":\"2022-06-14T22:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/en\\\/publication\\\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.retinegallien.com\\\/en\\\/publication\\\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/en\\\/publication\\\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\",\"item\":\"https:\\\/\\\/www.retinegallien.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/#website\",\"url\":\"https:\\\/\\\/www.retinegallien.com\\\/\",\"name\":\"R\u00e9tine Gallien\",\"description\":\"Cabinet Ophtalmologie \u00e0 Bordeaux\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.retinegallien.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/#organization\",\"name\":\"R\u00e9tine Gallien\",\"url\":\"https:\\\/\\\/www.retinegallien.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.retinegallien.com\\\/wp-content\\\/uploads\\\/2024\\\/12\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/www.retinegallien.com\\\/wp-content\\\/uploads\\\/2024\\\/12\\\/logo.png\",\"width\":322,\"height\":161,\"caption\":\"R\u00e9tine Gallien\"},\"image\":{\"@id\":\"https:\\\/\\\/www.retinegallien.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review - R\u00e9tine Gallien","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/","og_locale":"en_US","og_type":"article","og_title":"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review - R\u00e9tine Gallien","og_description":"Revista Brasileira de Oftalmologia&nbsp;81(10)&nbsp;April 2022 Andreas Di-Luciano1 , Wai-Ching Lam2 , Laurent Velasque3 , Eduardo Kenstelman4 ,Rodrigo M. Torres5 , Rosa Alvarado-Villacorta6 , Manish Nagpal71 Flying Eye Hospital, Orbis International, New York, United States.2 Deparment of Ophthalmology LKS Faculty of Medicine University Hong Kong, Hong Kong3 Centre Retine Gallien Bordeaux, France4 HOlhos S\u00e3o Gon\u00e7alo, Rio [&hellip;]","og_url":"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/","og_site_name":"R\u00e9tine Gallien","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/","url":"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/","name":"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review - R\u00e9tine Gallien","isPartOf":{"@id":"https:\/\/www.retinegallien.com\/#website"},"datePublished":"2022-06-14T22:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.retinegallien.com\/en\/publication\/disorganization-of-the-inner-retinal-layers-in-diabeticmacular-edema-systematic-review\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"","item":"https:\/\/www.retinegallien.com\/"},{"@type":"ListItem","position":2,"name":"Disorganization of the inner retinal layers in diabeticmacular edema: systematic review"}]},{"@type":"WebSite","@id":"https:\/\/www.retinegallien.com\/#website","url":"https:\/\/www.retinegallien.com\/","name":"R\u00e9tine Gallien","description":"Cabinet Ophtalmologie \u00e0 Bordeaux","publisher":{"@id":"https:\/\/www.retinegallien.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.retinegallien.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.retinegallien.com\/#organization","name":"R\u00e9tine Gallien","url":"https:\/\/www.retinegallien.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.retinegallien.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.retinegallien.com\/wp-content\/uploads\/2024\/12\/logo.png","contentUrl":"https:\/\/www.retinegallien.com\/wp-content\/uploads\/2024\/12\/logo.png","width":322,"height":161,"caption":"R\u00e9tine Gallien"},"image":{"@id":"https:\/\/www.retinegallien.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.retinegallien.com\/en\/wp-json\/wp\/v2\/publication\/1376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.retinegallien.com\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/www.retinegallien.com\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/www.retinegallien.com\/en\/wp-json\/wp\/v2\/media?parent=1376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}